COMPARISON BETWEEN THE MANAGEMENT AND OUTCOME OF TYPICAL AND ATYPICAL ANTIPSYCHOTIC DRUGS OVERDOSE: A STUDY FROM THE NATIONAL ENVIRONMENTAL AND CLINICAL TOXICOLOGY RESEARCH CENTRE, CAIRO UNIVERSITY HOSPITALS

Document Type : Original Article

Authors

1 Forensic and clinical toxicology department, Faculty of medicine, Cairo University

2 forensic and clinical toxicology department, faculty of medicine, Cairo University, Cairo, Egypt.

3 pharmacology department kasr alainy cairo University

4 Forensic and Clinical Toxicology department, Faculty of Medicine, Cairo University

Abstract

Objectives: The purpose of this study was to assess the effect of management on the outcome of antipsychotic drugs overdose in Egypt.
Methodology: This study was conducted on 75 cases presented to National Environmental and Clinical Toxicology research Centre, Cairo university hospitals with antipsychotic medications toxicity, from April 2018 to September 2018.
Results: The most common presenting age group was age group B; from 18-40 years (45.3%), females (68%), belonging to urban population (82.7%), educated (96.2%) and not working (89.3%). The majority of cases presented with abnormal CNS manifestation; altered conscious level (97.3%), abnormal pulse; tachycardia (98.7%) and abnormal pupil size; mydriasis or miosis (52%). Most of the cases did not do drug screening (98.7%), neither did decontamination (66.7%) nor receive antidote (100%), but most of them received supportive measures. Most of the cases were admitted (90.7%) and stayed in hospital more than 24 hours and less than one week. Regarding the outcome, most of the cases were cured (92.6%).

Keywords

The Egyptian Journal of Forensic Sciences and Applied Toxicology
Volume 23, Issue 1
March 2023
Pages 111-119

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