HISTOPATHOLOGICAL EFFECT OF PARAQUAT DICHLORIDE ON THE LIVER OF PREGNANT WISTAR RATS AT VARIOUS TRIMESTER

Document Type : Original Article

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1 =2348020760311

2 Human Anatomy and Cell Biology

3 HUMAN ANATOMY AND CELL BIOLOGY, BASIC MEDICAL SCIENCES, COLLEGE OF HEALTH SCIENCES, DELTA STATE UNIVERSITY, ABRAKA. DELTA STATE, NIGERIA consultant Pathology Delta State University teaching hospital Oghara. Delta State

Abstract

Background: Paraquat dichloride, a widely used herbicide, poses health and environmental risks due to its wide range of use in the modern-day Argo life, endangering aquatic life, farm animals, rodents and human health particularly, liver-related ailments, the aim of the study is to evaluate the effect of paraquat on the liver of pregnant Wistar rats at various trimesters. Material and Method: The study involved 24 pregnant Wistar rats divided into four groups: A (control), B, C and D (treated with 1mg/kg, 5mg/kg, 10mg/kg concentration of paraquat dichloride) each group comprised six rats. Throughout each trimester, two rats from each group were euthanize on day 7, 14, and 21 respectively. The concentrations (1mg/kg, 5mg/kg, 10mg/kg) were chosen below the lethal dose of 50mg/kg to induce graded dose histological changes in the liver. Result: The liver tissue initially appeared normal at day 7 across all group with varying doses. However, by day 14 and 21, significant histological changes were observed, such as central vein congestion, hemorrhages, degenerative changes, and bile duct hyperplasia. Conclusion: These finding highlight the changes that occurs with varying doses of paraquat exposure in the liver as pregnancy progresses in Wistar rats.

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The Egyptian Journal of Forensic Sciences and Applied Toxicology
Volume 24, Issue 3
September 2024
Pages 121-127

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