VITAMIN (E) PROTECTIVE ROLE AGAINST ROUNDUP TESTICULAR GENOTOXICITY IN MALE RATS

Document Type : Original Article

Authors

1 Lecturer of forensic medicine and clinical toxicology- Kasr Alaini- Cairo University

2 Lecturer of medical biochemistry and molecular biology, National Research Center

3 Lecturer of medical biochemistry and molecular biology .faculty of medicine, Beni sueif universty

Abstract

Round up, a worldwide herbicide has cellular and genotoxic effects. Round up’s genotoxicity was tested by detecting the expression of the steroidogenic acute regulatory, aromatase, estrogen and androgen receptor genes in testicular cells. Its cytotoxicity was examined by measuring caspase 3 gene expressions. Genes’ expressions were assessed by RT- PCR. Testicular lesions were detected by histopathological examination. We determined the role of vitamin E in reducing its toxic effects. Our study determined that Round up toxic doses caused endocrinal disruption through alteration of genes expression and effects on cellular integrity by increasing apoptosis. Administration of the vitamin E during exposure can reduce and protect against these endocrine cytogenotoxic effects.

Keywords

The Egyptian Journal of Forensic Sciences and Applied Toxicology
Volume 16, Issue 1
Forensic Topics
June 2016
Pages 1-10

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